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Good morning. Today’s cease story is on the newest landmark within the remedy of Alzheimer’s, as Eli Lilly launched trial outcomes that confirmed its new drug significantly slowed memory loss and cognitive decline.
The US prescribed drugs group on Monday reported full findings of its part 3 scientific examine of donanemab on the Alzheimer’s Association International Conference in Amsterdam, displaying that the antibody remedy slowed progression by about 35 per cent within the early phases of the illness.
The peer-reviewed outcomes comply with comparable part 3 findings launched final November by US biotech Biogen and Japan’s Eisai for lecanemab, one other antibody drug, which acquired full advertising approval from the US Food and Drug Administration this month below the model identify Leqembi.
Eli Lilly introduced on Monday that it had submitted donanemab for FDA approval and anticipated a call earlier than the top of this 12 months. Submissions are below method to different world regulators.
Experts on dementia known as Lilly’s donanemab presentation, printed within the Journal of the American Medical Association, a landmark within the subject.
“This is a watershed moment but it is just a start,” mentioned Howard Fillit, chief scientist on the US-based Alzheimer’s Drug Discovery Foundation. “We must continue advancing the drug pipeline to develop the next class centred around the biology of ageing to ultimately stop Alzheimer’s in its tracks.”
Here’s what else I’m preserving tabs on at this time:
Economic information: Canada stories June shopper worth index inflation price figures, the US releases retails gross sales and industrial manufacturing figures and the UK publishes Kantar grocery market share figures and worth inflation.
Results: Second-quarter earnings are due from Bank of America, BNY Mellon, Charles Schwab, Lockheed Martin, Morgan Stanley, PNC Financial Services and Prologis.
Meetings: The G20 assembly of finance ministers and central financial institution governors in Gujarat, India concludes. Meanwhile Japanese prime minister Fumio Kishida is expected to travel to Qatar, the third cease of a Gulf tour that has included visits to Saudi Arabia and the UAE. (Reuters)
Five extra prime tales
1. Russia has formally withdrawn from a UN-brokered deal to export Ukrainian grain throughout the Black Sea, probably imperilling tens of hundreds of thousands of tonnes of meals exports all over the world. Russia’s transfer is the second time that it has withdrawn from the grain deal, but folks concerned within the grain talks mentioned Moscow had appeared extra set on derailing the deal within the run-up to Monday’s deadline. Read the full story.
2. China’s outspoken international minister Qin Gang has not been seen in public for greater than three weeks, lacking essential diplomatic engagements and prompting rising hypothesis about his whereabouts. A Chinese international ministry spokeswoman mentioned she had “no information” about when Qin might return to his put up. Here’s more on Qin’s mysterious absence.
More China information: China’s economic system misplaced steam within the second quarter, with gross home product increasing 0.8 per cent towards the earlier three months. Here’s what’s behind China’s slowing growth.
China Focus: To show you how to discover our greatest work on China now we have created a special page on FT.com to serve as a hub for the newest information, evaluation and opinion on Asia’s greatest economic system.
3. Exclusive: Millions of US army emails have been misdirected to Mali by way of a “typo leak” that has uncovered extremely delicate info, together with diplomatic paperwork, tax returns, passwords and the journey particulars of prime officers. A common spelling error is behind the misdirected Pentagon messages, which have been collected by an organization working Mali’s web area.
4. Taiwan’s vice-president and the ruling social gathering candidate for January’s presidential elections, is to make two stops within the US on a visit to South America subsequent month, risking additional threats from China. Lai Ching-teh plans to cease over within the US on his method to and from the inauguration of Paraguay’s president Santiago Peña on August 15. Read more on Lai’s planned US stopover and Beijing’s reaction.
5. Bank analysts are sharply divided over simply how dangerous Goldman Sachs’ second-quarter earnings might be. While it isn’t unusual for analysts to disagree, the controversy over what Goldman will report on Wednesday is extra divided than traditional. Here’s why analysts are so uncertain.
The Big Read
As China’s financial progress has failed to decide up post-Covid, calls are rising louder for president Xi Jinping to resort to the playbook of the previous by launching a large-scale stimulus bundle to help the standard, debt-fuelled progress engines of infrastructure and property. But Xi and his prime policymakers are adhering to a stance they name dingli, or “maintaining strategic focus”. The query is, with the engines of progress stalling, will Beijing be able to stay the course?
We’re additionally studying . . .
Chart of the day
For the variety of feminine CEOs within the US and UK to enhance there should be a major shift in recruitment practices. Data analysed by the Financial Times reveals the frequent route to changing into boss remains to be overwhelmingly by way of finance and operational roles — areas dominated by men.
Take a break from the information
Who is the all-time biggest Chess participant? An eye-catching run of success from Magnus Carlsen, the world No1, has revived the long standing debate. Tell us what you suppose, and remedy this week’s puzzle: White mates the king in three strikes.
Additional contributions by Tee Zhuo and Gordon Smith